Ovatoxin-a

3/4/2015

Maximum growth rates were 0.59 ± 0.08 d(-1) for O. cf. ovata, 0.35 ± 0.01 d(-1) for C. monotis and 0.33 ± 0.04 d(-1) for P. lima. Toxin analyses revealed the presence of ovatoxin-a and ovatoxin-b in O. cf. ovata cells. (1) Lemée, R., Pesando, D., Durand-Clément, M., Dubreuil, A., Meinesz, A., Guerriero, A. & F. Pietra (1993) Preliminary survey of the toxicity of the green alga Ovatoxin A | C129H223N3O52 | CID 90479618 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities OVTX-a is about 100 fold less potent than PLTX in reducing HaCaT cells viability (EC 50 = 1.1 × 10 –9 M vs 1.8 × 10 –11 M, MTT test) in agreement with a reduced binding affinity (Kd = 1.2 × 10 –9 vs 2.7 × 10 –11 M, saturation experiments on intact cells). The ovatoxin was quantified using the PLTX standard.

08.12.2020

ovata in the Mediterranean Sea. Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve Jun 15, 2019 · The U.S. Army Medical Research Acquisition Activity (USAMRAA) is conducting market research to obtain information regarding services provide Isolation and purification of ovatoxin-a from O. ovata cell pellets to the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). Though palytoxin is 100 times as potent as ovatoxin-a, the isomer can still reach harmful levels in seawater during an algal bloom, Tubaro says. Dec 01, 2012 · An Italian Ostreopsis strain (KAC 85) was also analyzed by LC–MS as a reference material of Ostreopsis and the presence of ovatoxin-a, -b, -c, -d, and -e was re-confirmed. The most dominant palytoxin analogue in Japanese Ostreopsis was a novel palytoxin analogue, which was identified as an isomer of ovatoxin-a.

OVTX-a is about 100 fold less potent than PLTX in reducing HaCaT cells viability (EC 50 = 1.1 × 10 –9 M vs 1.8 × 10 –11 M, MTT test) in agreement with a reduced binding affinity (Kd = 1.2 × 10 –9 vs 2.7 × 10 –11 M, saturation experiments on intact cells).

ovata Fukuyo: Cytotoxic Activity and ELISA Detection. M. Pelin , M. Forino , +8 authors A. Tubaro Environmental science & technology This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf.

Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering.Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three

Jun 25, 2020 · Pelin M, Forino M, Brovedani V, Tartaglione L, Dell'Aversano C, Pistocchi R, Poli M, Sosa S, Florio C, Ciminiello P, Tubaro A. Ovatoxin-a, a palytoxin analogue isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic activity and ELISA detection. Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak P Ciminiello, C Dell’Aversano, E Fattorusso, M Forino, L Tartaglione, 42-hydroxypalytoxin, ostreocin-d, ovatoxin-a, -b,-c,-d, -e and -f and mascarenotoxin-a, -b and -c. However only the chemical structures of PLTX, ostreocin-d, ovatoxin-a and 42-hydroxypalytoxin have been characterized [4-11]. PLTX is a large molecule, with a molecular weight of 2659-2680 daltons depending on the origin [12,13]. Nov 24, 2008 · Two of the most remarkable properties of palytoxin are the large and complex structure (with different analogs, such as ostreocin‐D or ovatoxin‐a) and the extreme acute animal toxicity. The Na + /K + ‐ATPase has been proposed as receptor for palytoxin.

Feb 17, 2012 · The ovatoxin was quantified using the PLTX standard. The maximum levels found in terms of total PLTX equivalents (PLTX and ovatoxin-a) were approximately 175 µg and 450 µg eq PLTX/kg of total sea urchin flesh, in Iles de Frioul (August 2008) and Villefranche-sur-Mer (July 2008), respectively. 1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information. Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve molluscs (mussels) and herbivorous echinoderms (sea urchins). The total content accumulated in urchins reached 450 µg PLTX eq/kg total flesh (summer 2008).

Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve molluscs (mussels) and herbivorous echinoderms (sea urchins). The total content accumulated in urchins reached 450 µg PLTX eq/kg total flesh (summer 2008). A formerly unknown derivative of palytoxin, ovatoxin-a, produced as a marine aerosol by the tropical dinoflagellate Ostreopsis ovata caused hundreds of people in Genoa, Italy, to fall ill. In 2005 and 2006 blooms of these algae occurred in the Mediterranean sea. All those affected needed hospitalization. Jan 01, 2008 · LC-MS analyses indicated the occurrence of putative palytoxin along with a much more abundant palytoxin-like compound never reported so far, which we named ovatoxin-a. On the basis of molecular formula, fragmentation pattern, and chromatographic behavior, the structure of ovatoxin-a appeared to be strictly related to that of palytoxin.

Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three most cases ovatoxin-a was the only toxin detected (83 % of samples), and the remaining 17 % of samples contained it in association with ovatoxin-d/e. Alerted by the repeated occurrence of palytoxin-producing species in the Mediterranean, the European Food Safety Authority (EFSA), in its statement on the areas. At least 8 different PlTX analogues are known: PlTX, ostreocin-D, ovatoxin-A, homopalytoxin, bishomopalytoxin, neopalytoxin, deopalytoxin and 42-hydroxypalytoxin, but only for PlTX and ostreocin-D the chemical structure has been characterised. The occurrence data reported by European The aerosol LD50 values (0.063, 0.045, 0.041, and 0.031 μg/kg for the 50:50 mix, 42-OH PLTX, PLTX, and ovatoxin-a, respectively) confirmed the exquisite potency of PLTX suggested by the literature.

Mar 15, 2018 · Ovatoxin-a was found at the concentration of 78.8 µg/kg only in the soft tissue extract of T0 sea urchins, while the toxin was not detected in C animals 7 and decreased to undetectable levels Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve molluscs (mussels) and herbivorous echinoderms (sea urchins). The total content accumulated in urchins reached 450 µg PLTX eq/kg total flesh (summer Palytoxin is a polyol marine coelenterate toxin composed of substituted N-3-hydroxypropyl-trans-3-amidoacrylamides and produced by species of Palythoa and Zoanthus soft corals (collectively called zoantharians), either as a defence mechanism or to assist them in capturing prey. Ovatoxin-a MS2 2648.5 MS2 1315.7 MS2 896.2 MS3 727.4 MS3 507.3 MS3 327.1 MS4 309.1 Figure 1. Structure of palytoxin and HR LC-MSn-based structural hypothesis for ovatoxin-a. An NMR study [20] on pure ovatoxin-a demonstrated that ovatoxin-a is the 42-hydroxy-17,44,64-trideoxy-palytoxin. Cleavages resulting from various HR Sep 15, 2015 · In 2005, enormous blooms of the algae ovatoxin-a, a derivative of palytoxin, were produced by the Mediterranean tropical dinoflagellate Ostreopsis ovata.

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A formerly unknown derivative of palytoxin, ovatoxin-a, produced as a marine aerosol by the tropical dinoflagellate Ostreopsis ovata caused hundreds of people in Genoa, Italy, to fall ill. In 2005 and 2006 blooms of these algae occurred in the Mediterranean sea. All those affected needed hospitalization.

381-390. We've detected an unusually high number of searches coming from your location. Are you a real person, or a robot? P. Ciminiello, C. Dell'Aversano, E. Fattorusso et al., “Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the ligurian coasts during the 2006 toxic outbreak,” Journal of the American Society for Mass Spectrometry, vol. 19, no. 1, pp. 111–120, 2008.

26 Jul 2016 The most abundant palytoxin analogues in Mediterranean strains, Ovatoxin-a ( OVTX-a) and its analogues, can accumulate in several marine

The 2 Feb 2016 This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major Dinoflagellates of the genus Ostreopsis are known to cause (often fatal) food poisoning in tropical coastal areas following the accumulation of palytoxin (PLTX) 12 Oct 2020 Abstract and Figures. Dinoflagellates of the genus Ostreopsis are known to cause (often fatal) food poisoning in tropical coastal areas following Article. Putative Palytoxin and Its New Analogue, Ovatoxin-a, in Ostreopsis ovata Collected Along the Ligurian Coasts During the 2006 Toxic Outbreak. Author links to–e and revealed the presence of a new ovatoxin analogue, named ovatoxin-h. Ostreopsis cf. ovata extracts were pre-purified by Sephadex LH-20 to obtain a EnglishEdit. NounEdit.

Learn more about the change. Preparations of palytoxin (PLTX, derived from Japanese Palythoa tuberculosa) and the congeners 42-OH-PLTX (from Hawaiian P. toxica) and ovatoxin-a (isolated from a Japane Putative palytoxin and ovatoxins were detected, being ovatoxin-a the dominant component. The highest concentration per cell almost coincided with maximum Ostreopsis abundances. Novel Aspect: The improved UHPLC-HRMS method evidences the presence of putative palytoxin and ovatoxins in the Ostreopsis bloom in a NW Mediterranean beach.